19 of the Russian's 21 championships have been achieved on hardcourt
A comeback Medvedev secured his maiden trophy for 882 days with victory over Corentin Moutet in the competition final.
The Russian, a former top-ranked player, has endured a challenging period, achieving just one win at the Grand Slams and experiencing a difficult moment at the American major.
His unpredictability on the ATP Tour - and difficulties with his service game in particular - led to him exiting of the world's top 10 and ultimately splitting with long-time mentor Cervara.
Presently training with Thomas Johansson and his other coach, Medvedev has steadily progressed in the recent weeks - culminating in a tightly fought competitive victory over opponent Corentin Moutet.
It is his maiden championship following the Rome competition and initial on a hard court since March of 2023.
Success also signifies he has achieved twenty-one titles at 21 different competitions.
"This marks the first occasion I have attended a event with my both daughters at once, so to win a title is especially meaningful," said ranked player the champion.
"This championship is in tribute of my second daughter Victoria, because the initial championship I achieved when my child Alisa was born was for her."
Medvedev, the past champion, had been defeated in his last six title deciders, including in the German tournament in the past months.
His counter-punching approach and regular outbursts on the tennis court had led some to doubt if his ability to perform at the elite level was concluded.
But the athlete has implemented adjustments in the past month, making an effort to approach the net and perform positively, backed up by an enhanced service.
He recovered from a disadvantage in the opening set against the challenging Moutet, securing four of the last five games to go ahead.
The competitors swapped service breaks in the second set before Moutet, striving for his initial tour championship, seized the initiative to push for a third set.
He rescued 4 early-game opportunities in a tight final set before the Russian secured a break to fifteen to close out the victory.
Fittingly, he earned the win with a shot at the front of the court, with his opponent incapable to manage a volley after two hours and 38 minutes.